Application of Silver-Coated Magnetic Microspheres to a SERS-Based Optofluidic Sensor

Manager 2019.03.07 14:02 Views : 864

Year 2011 
Journal Info. The Journal of Physical Chemistry C, 115, 6290-6296 (2011). 
Author Byunghee Han, Namhyun Choi, Ki Hyung Kim, Dong Woo Lim, Jaebum Choo* 
etc.  

Abstract

Silver-coated magnetic microspheres (Fe3O4/Ag core/shell) were fabricated for use as a surface-enhanced Raman scattering (SERS) substrate. The surface morphology of the microspheres was characterized via field emission scanning electron microscopy and field emission  transmission electron microscopy. Energy-dispersive spectroscopy was also employed to analyze the elemental composition of the structures. Malachite green was used as a model analyte to evaluate the performance of the microspheres as a SERS-active substrate and validate the SERS effect. The prepared microspheres possessed both magnetic and SERS properties. In addition, a microfluidic device with solenoids was designed and fabricated for a facile trace analysis. The solenoid chip allowed us to control the alignment of the magnetic microspheres on the wall of the microfluidic channel. Target samples were introduced into the channel and adsorbed on the surface of trapped silver-coated magnetic microspheres. SERS signals were then measured using a confocal Raman microscope.  It is believed that a SERS-based optofluidic sensor with silver-coated magnetic microspheres can be successfully applied to microenvironmental analysis and other highly sensitive bioanalyses. 

 

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2012  SERS-based multiple biomarker detection using a gold-patterned microarray chip file Journal of Molecular Structure, 1023, 197-203 (2012).   
2012  SERS-based immunoassay using a gold array-embedded gradient microfluidic chip file Lab on a Chip, 19, 3720-3727 (2012).   
2012  Potential application of antibody-mimicking peptides identified by phage display in immuno-magnetic separation of an antigen file Journal of Biotechnology, 161, 213–220 (2012).   
2012  Simultaneous detection of duplex DNA oligonucleotides using a SERS-based micro-network gradient chip file Lab on a Chip, 12, 5160-5167 (2012).  Back Cover 
2011  Application of Silver-Coated Magnetic Microspheres to a SERS-Based Optofluidic Sensor file The Journal of Physical Chemistry C, 115, 6290-6296 (2011).   
2011  Ultrafast Surface Enhanced Resonance Raman Scattering Detection in Droplet-Based Microfluidic Systems file Analytical Chemistry, 83, 3076-3081 (2011).   
2011  Selective Trace Analysis of Mercury (II) Ions in Aqueous Media Using SERS-Based Aptamer Sensor file Bulletin of the Korean Chemical Society, 32, 2003-2007 (2011).   
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2011  Preparation of Silica-Encapsulated Hollow Gold Nanosphere Tags Using Layer-by-Layer Method for Multiplex Surface-Enhanced Raman Scattering Detection file Langmuir, 27, 10228-10233 (2011).   
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