Microfluidic gradient platforms for controlling cellular behavior

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Year 2010 
Journal Info. Electrophoresis, 31, 3014-3027 (2010). 
Author Bong Geun Chung and Jaebum Choo* 
etc. Review paper 
Abstract

Concentration AQ1 gradients play an important role in controlling biological and pathological processes, such as metastasis, embryogenesis, axon guidance, and wound healing. Microfluidic devices fabricated by photo- and soft lithography techniques can manipulate the fluidic flow and diffusion profile to create biomolecular gradients in a temporal and spatial manner. Furthermore, microfluidic devices enable the control of cell-extracellular microenvironment interactions, including cell–cell, cell–matrix, and cell–soluble factor interaction. In this paper, we review the development of microfluidic-based gradient devices and highlight their biological applications.

 

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