Colloidal gold nanoparticle conjugates of gefitinib

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Year 2014 
Journal Info. Colloids and Surfaces B: Biointerfaces, 123, 61–67 (2014) 
Author A. T. N. Lam, J. Yoon, E. Ganbold, D. K. Singh, D. Kim, K. H. Cho, S. Y. Lee, J. Choo, K. Lee, S. W. Joo* 
etc.  

Abstract

Gefitinib (GF) is a US Food and Drug Administration-approved epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitor for treating the lung cancers. We fabricated colloidal gold nanoparticle (AuNP)conjugates of the GF anticancer drug by self-assembly to test their potency against A549, NCI-H460,and NCI-H1975 lung cancer cells. GF adsorption on AuNP surfaces was examined by UV–vis absorptionspectra and surface-enhanced Raman scattering. Density functional theory calculations were performedto estimate the energetic stabilities of the drug-AuNP composites. The N1 nitrogen atom of the quinazolinering of GF was calculated to be more stable than the N3 in binding Au cluster atoms. The internalizationsof GF-coated AuNPs were examined by transmission electron and dark-field microscopy. A cell viabilitytest of AuNP–GF conjugates with the EGFR antibody exhibited much higher reductions than free GF forA549, NCI-H460, and NCI-H1975 lung cancer cells after treatment for 48 h.

 

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2014  Biosensors Using Surface-Enhanced Raman Scattering file In “Encyclopedia of Microfluidics and Nanofluidics”, pp. 1-6 (2014): Springer.  Book Chapter 
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