Surface-enhanced Raman scattering aptasensor for ultrasensitive trace analysis of bisphenol A

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Year 2015 
Journal Info. Biosensors & Bioelectronics, 64, 560–565 (2015) 
Author Eunsu Chung, Jinhyeok Jeon, Jimin Yu, Chankil Lee* and Jaebum Choo* 
etc.  

Abstract

Surface-enhanced Raman scattering (SERS)-based aptasensor platform, using double strand DNA-embedded Au/Ag core–shell nanoparticles, has been developed for the ultrasensitive detection of bisphenol A (BPA) in water. By combining optimally controlled Au/Ag core–shell nanoparticles with the selective BPA binding characteristics of DNA aptamers, a highly sensitive limit of detection (LOD) of 10fM could be achieved for BPA-spiked tap water over a wide concentration range from 100nM to 10fM. This LOD is two or three orders of magnitude lower than that reported for other BPA sensing techniques, and also yields a detection limit that is 100–1000 times lower than the USEPA-defined Predicted No Effect Concentration (PNEC) values in potable water. Total detection time is estimated to be about 40min including the reaction between aptamer and BPA (30min) and detection (10min). This sensing platform is also suitable for field applications since measurement can be performed under aqueous colloidal conditions.

 

 

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Year Title Journal Info. etc.
2015  Epitaxy-driven vertical growth of single-crystalline cobalt nanowire arrays by chemical vapor deposition file Journal of Materials Chemistry C, 3, 100-106 (2015)   
2015  Surface-enhanced Raman scattering aptasensor for ultrasensitive trace analysis of bisphenol A file Biosensors & Bioelectronics, 64, 560–565 (2015)   
2014  Rapid and sensitive phenotypic marker detection on breast cancer cells using surface-enhanced Raman scattering (SERS) imaging file Biosensors & Bioelectronics, 51, 238-243 (2014).   
2014  SERS-based competitive immunoassay of troponin I and CK-MB markers for early diagnosis of acute myocardial infarction file Chemical Communications, 50, 1058-1060 (2014).  Cover page 
2014  Quantitative Analysis of Disease Biomarkers Using Surface-Enhanced Raman Scattering Spectroscopy file In “Optical Spectroscopy and Computational Methods in Biology and Medicine”
Book Chapter 14 (2014). Springer 		 Book Chapter 
2014  Synthesis, Characterization and Directional Binding of Anisotropic Biohybrid Microparticles for Multiplexed Biosensing file Macromolecular Rapid Communications, 35, 56-65 (2014).   
2014  Detection of the mycotoxin citrinin using silver substrates and Raman spectroscopy file Journal of Hazardous Materials, 265, 89-95 (2014).   
2014  Ultrasensitive trace analysis for 2,4,6-trinitrotoluene using nano-dumbbell surface-enhanced Raman scattering hot spots file Analyst, 139, 807-812 (2014).   
2014  FITC functionalized magnetic core–shell Fe3O4/Ag hybrid nanoparticle for selective determination of molecular biothiols file Sensors and Actuators B, 193, 857-863 (2014).   
2014  One-Step Detection of Melamine in Milk by Hollow Gold Chip Based on Surface-enhanced Raman Scattering file Talanta, 122, 80-84 (2014).   
2014  Gold Nanorod-Assembled PEGylated Graphene-Oxide Nanocomposites for Photothermal Cancer Therapy file Photochemistry and Photobiology, 90, 659–666 (2014).   
2014  Interactions between the Antifungal Drug Myclobutanil and Gold and Silver Nanoparticles in Penicillium digitatum Investigated by Surface-Enhanced Raman Scattering file Applied Spectroscopy, 136, 3833-3841 (2014).   
2014  Gold Nanoparticle Silica Nanopeapods file Journal of the American Chemical Society, 136, 3833-3841 (2014).   
2014  Adsorption and desorption of tyrosine kinase inhibitor erlotinib on gold nanoparticles file Journal of Colloid and Interface Science, 425, 96–101 (2014).   
2014  A Flow Cytometry–based Submicron-Sized Bacterial Detection System using a Movable Virtual Wall file Lab on a Chip, 14, 2327–2333 (2014).   
2014  Use of surface-enhanced Raman scattering to quantify EGFR markers uninhibited by cetuximab antibodies file Biosensors and Bioelectronics, 60, 358–365 (2014).   
2014  Real-time analysis of diaquat dibromide monohydrate in water with a SERS-based integrated microdroplet sensor file Nanoscale, 6, 8781–8786 (2014).   
2014  SERS-based immunoassay of anti-cyclic citrullinated peptide for early diagnosis of rheumatoid arthritis file RSC Advances, 4, 32924-32927 (2014).   
2014  Colloidal gold nanoparticle conjugates of gefitinib file Colloids and Surfaces B: Biointerfaces, 123, 61–67 (2014)   
2014  Biosensors Using Surface-Enhanced Raman Scattering file In “Encyclopedia of Microfluidics and Nanofluidics”, pp. 1-6 (2014): Springer.  Book Chapter 
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