| Year | 2015 |
|---|---|
| Journal Info. | Analyst, 140, 3362-3367 (2015) |
| Author | DaBin Yim, Homan Kang, Su-Ji Jeon, Hye-In Kim, Jin-Kyoung Yang, Tae Wook Kang, Sangyeop Lee, Jaebum Choo, Yoon-Sik Lee, Jin Woong Kim* and Jong-Ho Kim* |
| etc. |
Abstract
Developing ultrasensitive Raman nanoprobes is one of the emerging interests in the field of biosensing and bioimaging. Herein, we constructed a new type of surface-enhanced resonance Raman scattering nanoprobe composed of an Ag nanoshell as a surface-enhanced Raman scattering-active nanostructure, which was encapsulated with 4,7,10-trioxa-1,13-tridecanediamine-functionalized graphene oxide as an ultrasensitive Raman reporter exhibiting strong resonance Raman scattering including distinct D and G modes. The designed nanoprobe was able to produce much more intense and simpler Raman signals even at a single particle level than the Ag nanoshell bearing a well-known Raman reporter, which is beneficial for the sensitive detection of a target in a complex biological system. Finally, this ultrasensitive nanoprobe successfully demonstrated its potential for bioimaging of cancer cells using Raman spectroscopy.
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