| Year | 2013 |
|---|---|
| Journal Info. | Bulletin of the Korean Chemical Society, 34, 3191-3192, (2013). |
| Author | Hyangah Chon, Soo-Ik Chang, Dong Woo Lim* and Jaebum Choo* |
| etc. |
Abstract
Angiogenesis, the process of new blood-vessel growth, plays an important role in normal physiological process. To date, angiogenin (ANG) is known to be a key factor in induction of angiogenesis by activation of endothelial and smooth muscle cells as well as by triggering a number of biological processes. It is also well known that the expression of ANG is up-regulated in various types of human cancers. This indicates that there is an intimate relationship between the expression of ANG and tumor development. Therefore, it is important to develop a highly sensitive immunoassay technique for ANG. At present, enzyme-linked immunosorbent assay (ELISA) is the most widely used immunoassay method in detection of the presence of ANG. Here, the fluorescence detection using molecular labels is generally used in most of cases. However, the poor limit of detection, long assay time, and photo-bleaching effect often limit its potential applications
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