Year 2021 
Journal Info. ACS Sensors, 6, 2378-2385 (2021) 
Author Hao Chen, Sung-Gyu Park, Namhyun Choi, Hyung-Jun Kwon, Taejoon Kang*, Mi-Kyung Lee*, and Jaebum Choo* 


We developed a new surface-enhanced Raman scattering (SERS)-based aptasensor platform capable of quantifying severe acute respiratory syndrome coronavirus 2 (SARS-CoV- 2) lysates with a high sensitivity. In this study, a spike protein deoxyribonucleic acid (DNA) aptamer was used as a receptor, and a self-grown Au nanopopcorn surface was used as a SERS detection substrate for the sensible detection of SARS-CoV-2. A quantitative analysis of the SARS-CoV-2 lysate was performed by monitoring the change in the SERS peak intensity caused by the new binding between the aptamer DNA released from the Au nanopopcorn surface and the spike protein in the SARS-CoV-2 virion. This technique enables detecting SARS-CoV-2 with a limit of detection (LoD) of less than 10 PFU/mL within 15 min. The results of this study demonstrate the possibility of a clinical application that can dramatically improve the detection limit and accuracy of the currently commercialized SARS-CoV-2 immunodiagnostic kit.

Year Title Journal Info. etc.
2022  Rapid and sensitive detection of lysophosphatidylcholine using Zwitterionic polydiacetylene liposome vesicles and a microfluidic gradient sensor Sensors & Actuators B, in press.   
2022  Dual-mode SERS-based lateral flow assay strips for simultaneous diagnosis of SARS-CoV-2 and influenza A virus Nano Convergence, in press.   
2022  Sensitive and reproducible detection of SARS-CoV-2 using SERS-based microdroplet sensor file Chemical Engineering Journal, 446, 137085 (2022)   
2022  A novel polymer-based nitrocellulose platform for implementing multiplexed microfluidic paper-based enzyme-linked immunosorbent assay file Microsystems & Nanoengineering, 8, 53 (2022)   
2022  Raman thermometry nanopipettes in cancer photothermal therapy file Analytical Chemistry, 94, 6463-6472 (2022)   
2022  Fluorescent probes for biomolecule detection under environmental stress file Journal of Hazardous Materials, 431, 128527 (2022)   
2022  Early and direct detection of bacterial signaling molecules through one-pot Au electrodeposition onto paper-based 3D SERS substrates file Sensors & Actuators B, 358, 131504 (2022)   
2022  iSERS Bioassays In “World Scientific Reference on Plasmonic Nanomaterials :
Principles, Design and Bio-applications. Vol. 5: Plasmonics in Diagnostics
and Therapy” Book Chapter 7, pp 239-265, World Scientific (2022) 
Book Chapter 
2022  Surface-Enhanced Raman Scattering-based Immunoassay for Severe Acute Respiratory Syndrome Coronavirus 2 file Biosensors & Bioelectronics, 202, 114008 (2022)   
2022  SERS-based dual-mode DNA aptasensors for rapid classification of SARS-CoV-2 and influenza A/H1N1 infection file Sensors & Actuators B, 355, 131324 (2022)   
2022  SERS-PCR Assays of SARS-CoV-2 target genes using Au nanoparticles-internalized Au nanodimple substrates file Biosensors & Bioelectronics, 197, 113736 (2022)   
2022  SERS-based microfluidic devices for in vitro diagnostics In "Principles and Clinical Diagnostic Applications of Surface-Enhanced
Raman Spectroscopy" Book Chapter 7, pp 281-302, Elsevier (2022) 
Book Chapter 
2021  Development of SERS-based immunoassay platforms using hollow Au nanostars for reliable SARS-CoV-2 diagnosis file Bull. Kor. Chem. Soc., 42, 1699-1705 (2021)   
2021  Reproducible and sensitive plasmonic sensing platforms based on Au-nanoparticle-internalized nanodimpled substrate file Advanced Functional Materials, 31, 2105703 (2021)  Cover page 
2021  SERS-based serodiagnosis of acute febrile diseases using plasmonic nanopopcorn microarray platforms file Biosensors & Bioelectronics, 192, 113525 (2021)   
2021  Coumarin–lipoic acid conjugates on silver nanoparticle-supported nanopipettes for in situ dual-mode monitoring of intracellular Cu(II) and potential chemodynamic therapy applications file Sensors & Actuators B, 344, 130271 (2021)   
2021  SERS-based test strips: Principles, designs and applications file Biosensors & Bioelectronics, 189, 113360 (2021)   
2021  Sensitive detection of SARS-CoV-2 using SERS-based aptasensor file ACS Sensors, 6, 2378-2385 (2021)   
2021  SERS-based Dual-flow Lateral Flow Assay Sensor for the Ultrasensitive Detection of Thyroid-Stimulating Hormone file Analytical Chemistry, 93, 6673-6681 (2021)   
2021  Molecular Imprinting: Green Perspectives and Strategies file Advanced Materials, 33, 2100543 (2021)